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1

Quantitative mass balance, tissue distribution, pharmacokinetics and biotransformation pathway of praliciguat, a clinical-stage sgc stimulator, after oral administration in rats

Banijamali, Ali, Carvalho, Andrew, Wakefield, James, Germano, Peter, Ribadeneira, Maria, Barden, Timothy, Zimmer, Daniel, Masferrer, Jaime, Profy, Albert, Currie, Mark, Milne, Todd, Germano, Peter

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2019

Language:

english

File:

PDF, 66 KB

english, 2019

2

4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

John J. Talley, Stephen R. Bertenshaw, David L. Brown, Jeffery S. Carter, Mathew J. Graneto, Carol M. Koboldt, Jaime L. Masferrer, Bryan H. Norman, D. Joseph Rogier Jr., Ben S. Zweifel, Karen Seibert

Journal:

Medicinal Research Reviews

Year:

1999

Language:

english

File:

PDF, 96 KB

english, 1999

3

ChemInform Abstract: Synthesis and Activity of Sulfonamide-Substituted 4,5-Diaryl Thiazoles as Selective Cyclooxygenase-2 Inhibitors.

Jeffery S. Carter, Steven Kramer, John J. Talley, Thomas Penning, Paul Collins, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Jaime Masferrer, Ben Zweifel

Journal:

Year:

1999

File:

PDF, 33 KB

1999

4

Development of a fluorescence-based enzyme assay of human 5-lipoxygenase

Robert A. Pufahl, Thomas P. Kasten, Rob Hills, James K. Gierse, Beverly A. Reitz, Robin A. Weinberg, Jaime L. Masferrer

Journal:

Analytical Biochemistry

Year:

2007

Language:

english

File:

PDF, 289 KB

english, 2007

5

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates

Jane L. Wang, Karl Aston, David Limburg, Cindy Ludwig, Ann E. Hallinan, Francis Koszyk, Bruce Hamper, David Brown, Matthew Graneto, John Talley, Timothy Maziasz, Jaime Masferrer, Jeffery Carter

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 742 KB

english, 2010

6

Synthesis and Structure Confirmation Of Compound D, A Proinflammatory Arachidonate Metabolite

Dong-Soo Shin, Pendri Yadagiri, J.R. Falck, Jaime L. Masferrer, Michal L. Schwartzman

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 180 KB

english, 1989

7

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter, Steven Kramer, John J. Talley, Thomas Penning, Paul Collins, Matthew J. Graneto, Karen Seibert, Carol M. Koboldt, Jaime Masferrer, Ben Zweifel

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 205 KB

english, 1999

8

Pharmacologic Evaluation of Sulfasalazine, FTY720, and Anti-IL-12/23p40 in a TNBS-Induced Crohn’s Disease Model

Zaher A. Radi, Deborah M. Heuvelman, Jaime L. Masferrer, Ericka L. Benson

Journal:

Digestive Diseases and Sciences

Year:

2011

Language:

english

File:

PDF, 201 KB

english, 2011

9

COX-2 Inhibitors: A New Class of Antiangiogenic Agents

JAIME L. MASFERRER, ALANE KOKI, KAREN SEIBERT

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

10

Cyclooxygenase-1 derived prostaglandins are involved in the maintenance of renal function in rats with cirrhosis and ascites

Marta López-Parra, Joan Clària, Anna Planagumà, Esther Titos, Jaime L Masferrer, B Mark Woerner, Alane T Koki, Wladimiro Jiménez, Rosario Altuna, Vicente Arroyo, Francisca Rivera, Joan Rodés

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 574 KB

english, 2002

11

A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors

Ben S. Zweifel, Medora M. Hardy, Gary D. Anderson, Dawn R. Dufield, Robert A. Pufahl, Jaime L. Masferrer

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 586 KB

english, 2008

12

Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors

James Gierse, Maureen Nickols, Kathleen Leahy, James Warner, Yan Zhang, Luz Cortes-Burgos, Jeffery Carter, Karen Seibert, Jaime Masferrer

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 494 KB

english, 2008

13

Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2

Yoel Sadovsky, D.Michael Nelson, Louis J. Muglia, Gilad A. Gross, Katherine C. Harris, Alane Koki, Jaime L. Masferrer, Lisa M. Olson

Journal:

American Journal of Obstetrics and Gynecology

Year:

2000

Language:

english

File:

PDF, 93 KB

english, 2000

14

Celecoxib: A specific COX-2 inhibitor with anti-angiogenic and anti-cancer activities

Jaime L. Masferrer, Kathleen Leahy, Ben S. Zweifel, Rosalyn Moore, Debra Heuvelman, Alane Koki, Karen Seibert

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 63 KB

english, 1999

15

Characterization of cyclooxygenase-2 in human pathological disease

Alane Koki, Nasir K. Khan, B. Mark Woerner, A.J. Dannenberg, Lisa Olson, Karen Seibert, Dorothy Edwards, Madorra Hardy, Jaime L. Masferrer

Journal:

Prostaglandins and Other Lipid Mediators

Year:

1999

Language:

english

File:

PDF, 73 KB

english, 1999

16

Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney

Karen Seibert, Jaime L. Masferrer, Philip Needleman, Daniela Salvemini

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 929 KB

english, 1996

17

Cytochrome P450 dependent metabolism of arachidonic acid in bovine corneal epithelium

Michal L. Schwartzman, Nader G. Abraham, Jaime Masferrer, Michael W. Dunn, John C. McGiff

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 974 KB

english, 1985

18

Isolation and characterization of rat plasma glandular kallikrein

Jaime Masferrer, Renato Albertini, Héctor R. Croxatto, Pilar García, Inés Pinto

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 686 KB

english, 1985

19

Inhibition of renal, cardiac and corneal (Na+−K+ATPase by 12(R)-hydroxyeicosatetraenoic acid

Jaime L. Masferrer, Amelia P. Rios, Michal Laniado Schwartzman

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 473 KB

english, 1990

20

Modulation of vascular tone by 12(R)-, but not 12(S)-, hydroxyeicosatetraenoic acid

Jaime Masferrer, Kevin M. Mullane

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 303 KB

english, 1988

21

12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea

Jaime L. Masferrer, Julio A. Rimarachin, Mary E. Gerritsen, J.R. Falck, P. Yadagiri, Michael W. Dunn, Michal Laniado-Schwartzman

Journal:

Experimental Eye Research

Year:

1991

Language:

english

File:

PDF, 3.76 MB

english, 1991

22

The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARγ. Influence of albumin

Marta López-Parra, Joan Clària, Esther Titos, Anna Planagumà, Marcelina Párrizas, Jaime L. Masferrer, Wladimiro Jiménez, Vicente Arroyo, Francisca Rivera, Joan Rodés

Journal:

Journal of Hepatology

Year:

2005

Language:

english

File:

PDF, 299 KB

english, 2005

23

Cyclooxygenase-2 inhibitors: A new approach to the therapy of ocular inflammation

Jaime L. Masferrer, Prasad S. Kulkarni

Journal:

Survey of Ophthalmology

Year:

1997

Language:

english

File:

PDF, 541 KB

english, 1997

24

Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis

Melissa B Hansen-Petrik, Michael F McEntee, Benjamin T Johnson, Mark G Obukowicz, Jaime Masferrer, Ben Zweifel, Chun-Hung Chiu, Jay Whelan

Journal:

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

25

Regulation of prostaglandin production by nitric oxide; an in vivo analysis

Daniela Salvemini, Steven. L. Settle, Jaime. L. Masferrer, Karen Seibert, Mark. G. Currie, Philip Needleman

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.44 MB

english, 1995

26

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

Talley, John J., Brown, David L., Carter, Jeffery S., Graneto, Matthew J., Koboldt, Carol M., Masferrer, Jaime L., Perkins, William E., Rogers, Roland S., Shaffer, Alexander F., Zhang, Yan Y., Zweifel

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 43 KB

english, 2000

27

Anti-PDGF-B monoclonal antibody reduces liver fibrosis development

Shinji Ogawa, Takashi Ochi, Hideaki Shimada, Kazuyuki Inagaki, Isami Fujita, Aisuke Nii, Mark A. Moffat, Madan Katragadda, Bernard N. Violand, Robert H. Arch, Jaime L. Masferrer

Journal:

Hepatology Research

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

28

Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites

Marta Bosch–Marcé*, Joan Clària*, Esther Titos*, Jaime L. Masferrer‡, Rosario Altuna§, Jorge–Luís Poo∥, Wladimiro Jiménez¶, Vicente Arroyo∥, Francisca Rivera¶, Joan Rodés∥

Journal:

Gastroenterology

Year:

1999

Language:

english

File:

PDF, 253 KB

english, 1999

29

Cytokine Regulation of Eicosanoid Generation

PETER ISAKSON, SCOTT HAUSER, YAN ZHANG, KATHLEEN LEAHY, JAIME MASFERRER, KAREN SEIBERT

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 149 KB

english, 1994

30

Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Li, James J., Norton, Monica B., Reinhard, Emily J., Anderson, Gary D., Gregory, Susan A., Isakson, Peter C., Koboldt, Carol M., Masferrer, Jaime L., Perkins, William E., Seibert, Karen, Zhang, Yan, Z

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 414 KB

english, 1996

31

Highly Specific and Sensitive Measurements of Human and Monkey Interleukin 21 Using Sequential Protein and Tryptic Peptide Immunoaffinity LC-MS/MS

Palandra, Joe, Finelli, Alyce, Zhu, Ming, Masferrer, Jaime, Neubert, Hendrik

Journal:

Analytical Chemistry

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

32

Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Khanna, Ish K., Yu, Yi, Huff, Renee M., Weier, Richard M., Xu, Xiangdong, Koszyk, Francis J., Collins, Paul W., Cogburn, J. Nita, Isakson, Peter C., Koboldt, Carol M., Masferrer, Jaime L., Perkins, Wi

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 390 KB

english, 2000

33

CYCLOOXYGENASE-2 INHIBITORS

Masferrer, Jaime L., Isakson, Peter C., Seibert, Karen

Journal:

Gastroenterology Clinics of North America

Year:

1996

Language:

english

File:

PDF, 634 KB

english, 1996

34

Role of cyclooxygenase-2 in inflammation

Seibert, Karen, Masferrer, Jaime, Isakson, Peter

Journal:

Pathophysiology

Year:

1994

Language:

english

File:

PDF, 89 KB

english, 1994

35

12(R)-Hydroxyicosatetraenoic Acid: A Cytochrome P450-Dependent Arachidonate Metabolite that Inhibits Na+,K+-ATPase in the Cornea

Michal L. Schwartzman, Michal Balazy, Jaime Masferrer, Nader G. Abraham, John C. McGiff and Robert C. Murphy

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 899 KB

english, 1987

36

Pharmacological Analysis of Cyclooxygenase-1 in Inflammation

Christopher J. Smith, Yan Zhang, Carol M. Koboldt, Jerry Muhammad, Ben S. Zweifel, Alex Shaffer, John J. Talley, Jaime L. Masferrer, Karen Seibert and Peter C. Isakson

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.53 MB

english, 1998

37

Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy

Koki, Alane T, Leahy, Kathleen M, Masferrer, Jaime L

Journal:

Expert Opinion on Investigational Drugs

Year:

1999

Language:

english

File:

PDF, 433 KB

english, 1999

38

1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Khanna, Ish K., Weier, Richard M., Yu, Yi, Xu, Xiang D., Koszyk, Francis J., Collins, Paul W., Koboldt, Carol M., Veenhuizen, Amy W., Perkins, William E., Casler, Jacquelen J., Masferrer, Jaime L., Zh

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 377 KB

english, 1997

39

Cytochrome P450, drug metabolizing enzymes and arachidonic acid metabolism in bovine ocular tissues

Schwartzman, Michal L., Masferrer, Jaime, Dunn, Michael W., McGiff, John C., Abraham, Nader G.

Journal:

Current Eye Research

Year:

1987

Language:

english

File:

PDF, 644 KB

english, 1987

40

Tu1863 Linaclotide Induces Secretion of cGMP Into the Colonic Submucosal Layer: An In Vivo Microdialysis Study in Rats

Tobin, Jenny, Thomas, Sara, Solinga, Robert, Masferrer, Jaime L., Lunte, Craig, Silos-Santiago, Inmaculada

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 727 KB

english, 2015

41

Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells

Wang, Xing, Heuvelman, Deborah M., Carroll, James A., Dufield, Dawn R., Masferrer, Jaime L.

Journal:

Cancer Investigation

Year:

2010

Language:

english

File:

PDF, 329 KB

english, 2010

42

Treatment of Life-Threatening Infantile Hemangiomas with Vincristine

Payarols, Jaime Perez, Masferrer, Jose Pardo, Bellvert, Cristina Gomez

Journal:

Boston Medical and Surgical Journal

Year:

1995

Language:

english

File:

PDF, 229 KB

english, 1995

43

Nitric Oxide Activates Cyclooxygenase Enzymes

Daniela Salvemini, Thomas P. Misko, Jaime L. Masferrer, Karen Seibert, Mark G. Currie and Philip Needleman

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 903 KB

english, 1993

44

Evidence That Relaxin’s Effects on Growth and Softening of the Cervix Are Not Mediated through Prostaglandins in the Rat 1

Sherwood, O. David, Jungheim, Emily S., Masferrer, Jaime L., Cramer, Joyce M.

Journal:

Year:

1998

Language:

english

File:

PDF, 272 KB

english, 1998

45

10.1097/00000421-200308002-00004

Davis, Thomas, Hunter, Nancy, Trifan, Ovidiu, Milas, Luka, Masferrer, Jaime

Journal:

American Journal of Clinical Oncology

Year:

2003

Language:

english

File:

PDF, 598 KB

english, 2003

46

Leukotrienes, But Not Angiotensin II, Are Involved in the Renal Effects Elicited by the Prolonged Cyclooxygenase-2 Inhibition When Sodium Intake Is Low

Salazar, Francisco, Salazar, F. Javier, Saez, Fara, Reverte, Virginia, Zweifel, Ben, Dufield, Dawn, Radabaugh, Melissa, Graneto, Matt, Llinas, Maria T., Masferrer, Jaime L.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2013

Language:

english

File:

PDF, 270 KB

english, 2013

47

NITRIC OXIDE ACTIVATES THE CYCLOOXYGENASE PATHWAY IN INFLAMMATION

Salvemini, Daniela, Seibert, Karen, Masferrer, Jaime L., Settle, Steven L., Currie, Mark G., Needleman, Philip

Journal:

American Journal of Therapeutics

Year:

1995

File:

PDF, 325 KB

1995

48

THE ROLE OF CYCLOOXYGENASE-2 IN INFLAMMATION

Masferrer, Jaime L., Zweifel, Ben S., Colburn, Susan M., Ornberg, Richard L., Salvemini, Daniela, Isakson, Peter, Seibert, Karen

Journal:

American Journal of Therapeutics

Year:

1995

File:

PDF, 382 KB

1995

49

COX-2 Inhibitors as Radiosensitizing Agents for Cancer Therapy

Davis, Thomas W., Hunter, Nancy, Trifan, Ovidiu C., Milas, Luka, Masferrer, Jaime L.

Journal:

American Journal of Clinical Oncology

Year:

2003

Language:

english

File:

PDF, 598 KB

english, 2003

50

Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic

Jaime L. Masferrer, Ben S. Zweifel, Pamela T. Manning, Scott D. Hauser, Kathleen M. Leahy, Walter G. Smiith, Peter C. Isakson and Karen Seibert

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.28 MB

english, 1994